RAR-related orphan receptor alpha
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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RAR-related orphan receptor alpha (RORα), also known as NR1F1 (nuclear receptor subfamily 1, group F, member 1) is a nuclear receptor that in humans is encoded by the RORA gene.[5] RORα participates in the transcriptional regulation of some genes involved in circadian rhythm.[6] In mice, RORα is essential for development of cerebellum[7][8] through direct regulation of genes expressed in Purkinje cells.[9] It also plays an essential role in the development of type 2 innate lymphoid cells (ILC2) and mutant animals are ILC2 deficient.[10][11] In addition, although present in normal numbers, the ILC3 and Th17 cells from RORα deficient mice are defective for cytokine production.[12]