Sigma receptor
Class of cell surface receptors / From Wikipedia, the free encyclopedia
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Sigma receptors (σ-receptors) are protein cell surface receptors that bind ligands such as 4-PPBP (4-phenyl-1-(4-phenylbutyl) piperidine),[1] SA 4503 (cutamesine), ditolylguanidine, dimethyltryptamine,[2] and siramesine.[3] There are two subtypes, sigma-1 receptors (σ1) and sigma-2 receptors (σ2), which are classified as sigma receptors for their pharmacological similarities, even though they are evolutionarily unrelated.
This article may be too technical for most readers to understand. (August 2020) |
ERG2/Sigma-1 receptor | |||||||||
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Identifiers | |||||||||
Symbol | ERG2_Sigma1R | ||||||||
Pfam | PF04622 | ||||||||
InterPro | IPR006716 | ||||||||
TCDB | 8.A.63 | ||||||||
OPM superfamily | 446 | ||||||||
OPM protein | 5hk1 | ||||||||
Membranome | 1025 | ||||||||
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The fungal protein ERG2, a C-8 sterol isomerase, falls into the same protein family as sigma-1. Both localize to the ER membrane, although sigma-1 is also reported to be a cell surface receptor. Sigma-2 is an EXPREA domain protein[4] with a mostly intracellular (ER membrane) localization.[5]