Toll-like receptor 9
Protein found in humans / From Wikipedia, the free encyclopedia
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Toll-like receptor 9 is a protein that in humans is encoded by the TLR9 gene.[5] TLR9 has also been designated as CD289 (cluster of differentiation 289). It is a member of the toll-like receptor (TLR) family. TLR9 is an important receptor expressed in immune system cells including dendritic cells, macrophages, natural killer cells, and other antigen presenting cells.[5] TLR9 is expressed on endosomes internalized from the plasma membrane, binds DNA (preferentially DNA containing unmethylated CpGs of bacterial or viral origin), and triggers signaling cascades that lead to a pro-inflammatory cytokine response.[6][7] Cancer, infection, and tissue damage can all modulate TLR9 expression and activation.[7][8][9][10][11] TLR9 is also an important factor in autoimmune diseases, and there is active research into synthetic TLR9 agonists and antagonists that help regulate autoimmune inflammation.[10][12]