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Trimipramine
Antidepressant / From Wikipedia, the free encyclopedia
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Trimipramine, sold under the brand name Surmontil among others, is a tricyclic antidepressant (TCA) which is used to treat depression.[6][7][8][9] It has also been used for its sedative, anxiolytic, and weak antipsychotic effects in the treatment of insomnia, anxiety disorders, and psychosis, respectively.[6][7][8][9] The drug is described as an atypical or "second-generation" TCA because, unlike other TCAs, it seems to be a fairly weak monoamine reuptake inhibitor.[10] Similarly to other TCAs, however, trimipramine does have antihistamine, antiserotonergic, antiadrenergic, antidopaminergic, and anticholinergic activities.[6][7][8][9]
Quick Facts Clinical data, Trade names ...
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Clinical data | |
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Trade names | Surmontil, others |
Other names | Trimeproprimine; IF-6120; IL-6001; RP-7162; 2'-Methylimipramine; β-Methylimipramine |
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MedlinePlus | a602010 |
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Routes of administration | Oral, intramuscular injection, intravenous |
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Bioavailability | 41%[2][3][4][5] |
Protein binding | 94.9%[2][3][4][5] |
Metabolism | Hepatic[2][3][4][5] |
Elimination half-life | 23–24 hours[2][3][4][5] |
Excretion | Renal[2][3][4][5] |
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ECHA InfoCard | 100.010.917 ![]() |
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Formula | C20H26N2 |
Molar mass | 294.442 g·mol−1 |
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