Verapamil
Calcium channel blocker medication / From Wikipedia, the free encyclopedia
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Verapamil, sold under various trade names,[1] is a calcium channel blocker medication used for the treatment of high blood pressure, angina (chest pain from not enough blood flow to the heart), and supraventricular tachycardia.[7] It may also be used for the prevention of migraines and cluster headaches.[8][9] It is given by mouth or by injection into a vein.[7]
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Pronunciation | /vɛˈræpəmɪl/ ve-RAP-ə-mil |
Trade names | Isoptin, Calan, others[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a684030 |
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Routes of administration | By mouth, intravenous |
Drug class | Calcium channel blocker |
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Bioavailability | 35.1% |
Metabolism | Liver |
Elimination half-life | 2.8–7.4 hours[6] |
Excretion | Kidney: 11% |
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ECHA InfoCard | 100.000.133 |
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Formula | C27H38N2O4 |
Molar mass | 454.611 g·mol−1 |
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Chirality | Racemic mixture |
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Common side effects include headache, low blood pressure, nausea, and constipation.[7] Other side effects include allergic reactions and muscle pains.[10] It is not recommended in people with a slow heart rate or heart failure.[10] It is believed to cause problems for the fetus if used during pregnancy.[2] It is in the non–dihydropyridine calcium channel blocker family of medications.[7]
Verapamil was approved for medical use in the United States in 1981.[7][11] It is on the World Health Organization's List of Essential Medicines.[12][13] Verapamil is available as a generic medication.[7] Long acting formulations exist.[10] In 2021, it was the 196th most commonly prescribed medication in the United States, with more than 2 million prescriptions.[14][15]