Protein sa homeoboksom 1, znan i kao protein 1 sa homeoboksnim vezanjem telomere (HOT1), je protein koji je kod ljudi kodiran genom HMBOX1.[5] HMBOX1 directly binds to the double-stranded repeat sequence of telomeres.[6][7]
Kratke činjenice Dostupne strukture, PDB ...
HMBOX1 |
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Identifikatori |
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Aliasi | HMBOX1 |
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Vanjski ID-jevi | MGI: 2445066 HomoloGene: 11589 GeneCards: HMBOX1 |
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Ontologija gena |
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Molekularna funkcija | • vezivanje sa DNK • telomerase activity • double-stranded telomeric DNA binding • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje identičnih proteina • telomeric DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • sequence-specific DNA binding • GO:0032403 protein-containing complex binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
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Ćelijska komponenta | • citoplazma • jedro • telomerase holoenzyme complex • nukleoplazma • citosol • nuclear body • Telomera • hromosom • Cajal body • PML body
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Biološki proces | • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of telomere maintenance via telomerase • GO:0045996 negative regulation of transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • positive regulation of telomerase activity • transcription, DNA-templated • RNA-dependent DNA biosynthetic process • positive regulation of chromatin binding • GO:1901227 negative regulation of transcription by RNA polymerase II • regulation of telomerase activity
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 8: 28.89 – 29.06 Mb | Chr 14: 65.05 – 65.19 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori