Razlikovati: Pura.
Pur-alfa jest protein koji je kod ljudi kodiran genom PURA sa hromosoma 5, sekvenca q31.[5][6][7]
Kratke činjenice Identifikatori, Aliasi ...
PURA |
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Identifikatori |
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Aliasi | PURA |
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Vanjski ID-jevi | OMIM: 600473 MGI: 103079 HomoloGene: 4279 GeneCards: PURA |
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Ontologija gena |
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Molekularna funkcija | • vezivanje sa DNK • double-stranded telomeric DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • purine-rich negative regulatory element binding • translation repressor activity, mRNA regulatory element binding • single-stranded DNA binding • GO:0001948, GO:0016582 vezivanje za proteine • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • double-stranded DNA binding • SMAD binding • vezivanje sa RNK • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • sequence-specific DNA binding
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Ćelijska komponenta | • citoplazma • neuronal cell body • dendrit • Replikacijski protein A • jedro • dendrite cytoplasm • postsynapse • glutamatergic synapse
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Biološki proces | • Ćelijska diferencijacija • negative regulation of translation • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • nervous system development • regulation of cell population proliferation • DNA replication initiation • positive regulation of cell population proliferation • GO:0045996 negative regulation of transcription, DNA-templated • DNA unwinding involved in DNA replication • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:1901227 negative regulation of transcription by RNA polymerase II • dendritic transport of messenger ribonucleoprotein complex • lymphocyte proliferation • epithelial cell proliferation
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 5: 140.11 – 140.13 Mb | Chr 18: 36.41 – 36.43 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori
Pur-alfa je drevni, multifunkcionalni DNK– i RNK-vezujući protein.[5][8] PURA je eksprimiran u svim ljudskim tkivima, gdje postoji kao protein od 322 aminokiseline. Prema konvenciji, gen "PURA", napisan je kurzivom svim velikim slovima. Protein Pur-alfa, napisan je velikim slovom i može se naći kao Pur-alfa, Pur-α, Pura, Puralfa, Pur alfa i Pur1.