Receptor retinoidne kiseline beta (RAR-beta), znan i kao NR1B2 (član 2 B grupe potporodice 1 jedarnog receptora) je jedarni receptor jest protein koji je kod ljudi kodiran genom RARB sa hromosoma 3.[5][6]
Kratke činjenice Dostupne strukture, PDB ...
RAR-beta |
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Identifikatori |
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Aliasi | RARB |
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Vanjski ID-jevi | OMIM: 180220 MGI: 97857 HomoloGene: 68100 GeneCards: RARB |
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Ontologija gena |
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Molekularna funkcija | • vezivanje sa DNK • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • vezivanje iona cinka • vezivanje iona metala • steroid hormone receptor activity • GO:0001948, GO:0016582 vezivanje za proteine • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0032403 protein-containing complex binding • retinoid X receptor binding • GO:0000975 transcription cis-regulatory region binding • transcription factor binding • nuclear receptor coactivator activity • signaling receptor activity • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity
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Ćelijska komponenta | • citoplazma • nukleoplazma • jedro • RNA polymerase II transcription regulator complex
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Biološki proces | • growth plate cartilage development • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • neurogenesis • ureteric bud development • GO:0009373 regulation of transcription, DNA-templated • negative regulation of cartilage development • multicellular organism growth • embryonic eye morphogenesis • positive regulation of programmed cell death • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • retinal pigment epithelium development • transcription, DNA-templated • outflow tract septum morphogenesis • negative regulation of chondrocyte differentiation • retinoic acid receptor signaling pathway • regulation of myelination • retina development in camera-type eye • positive regulation of neuron differentiation • positive regulation of cell population proliferation • positive regulation of apoptotic process • ventricular cardiac muscle cell differentiation • transcription initiation from RNA polymerase II promoter • bone development • embryonic digestive tract development • striatum development • GO:0072468 Transdukcija signala • negative regulation of cell population proliferation • glandular epithelial cell development • steroid hormone mediated signaling pathway • embryonic hindlimb morphogenesis • liver development • multicellular organism development • hormone-mediated signaling pathway • Ćelijska diferencijacija • response to retinoic acid • response to lipid • gland development • bone morphogenesis • epithelium development • cellular response to retinoic acid
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 3: 24.69 – 25.6 Mb | Chr 14: 5.65 – 6.04 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori