Protein sy'n cael ei godio yn y corff dynol gan y genyn FOXO1 yw FOXO1 a elwir hefyd yn Forkhead box O1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 13, band 13q14.11.[2]
Ffeithiau sydyn Strwythurau, PDB ...
FOXO1 |
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Strwythurau |
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PDB | Human UniProt search: PDBe RCSB |
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Dynodwyr |
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Cyfenwau | FOXO1, FKH1, FKHR, FOXO1A, forkhead box O1 |
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Dynodwyr allanol | OMIM: 136533 HomoloGene: 1527 GeneCards: FOXO1 |
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Ontoleg y genyn |
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Gweithrediad moleciwlaidd | • sequence-specific DNA binding • DNA binding • beta-catenin binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • chromatin binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • protein phosphatase 2A binding • ubiquitin protein ligase binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • transcription coactivator binding
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Cydrannau o'r gell | • cytoplasm • cytosol • nucleoplasm • mitocondria • cnewyllyn cell
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Prosesau biolegol | • GO:1901047 insulin receptor signaling pathway • negative regulation of fat cell differentiation • GO:0009373 regulation of transcription, DNA-templated • GO:1903364 positive regulation of protein catabolic process • glucose homeostasis • positive regulation of autophagy • cellular glucose homeostasis • cellular response to hyperoxia • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • cellular response to starvation • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:1904489 regulation of reactive oxygen species metabolic process • transcription, DNA-templated • regulation of neural precursor cell proliferation • cellular response to dexamethasone stimulus • cellular response to DNA damage stimulus • neuronal stem cell population maintenance • autophagy • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • response to insulin • blood vessel development • cellular response to cold • response to fluoride • regulation of cell population proliferation • cellular response to insulin stimulus • positive regulation of apoptotic process • negative regulation of stress-activated MAPK cascade • cellular response to oxidative stress • enamel mineralization • cellular response to nitric oxide • positive regulation of gluconeogenesis • temperature homeostasis • GO:0045996 negative regulation of transcription, DNA-templated • fat cell differentiation • negative regulation of canonical Wnt signaling pathway • endocrine pancreas development • protein acetylation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cellular response to hydrogen peroxide • GO:0097285 apoptotic process • anatomical structure morphogenesis • cell differentiation • negative regulation of cardiac muscle hypertrophy in response to stress • cytokine-mediated signaling pathway • energy homeostasis
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Sources:Amigo / QuickGO |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Cau