UGDH

UGDH
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2Q3E, 2QG4, 3ITK, 3KHU, 3PRJ, 3PTZ, 3TDK, 3TF5, 4EDF, 4QEJ, 4RJT
Dynodwyr
Cyfenwau	UGDH, GDH, UDP-GlcDH, UDPGDH, UGD, UDP-glucose 6-dehydrogenase, EIEE84, DEE84
Dynodwyr allanol	OMIM: 603370 HomoloGene: 2520 GeneCards: UGDH
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• NAD binding; • catalytic activity; • oxidoreductase activity; • electron transfer activity; • GO:0050229 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; • UDP-glucose 6-dehydrogenase activity;
Cydrannau o'r gell	• nucleoplasm; • extracellular exosome; • cnewyllyn cell; • cytosol;
Prosesau biolegol	• UDP-glucuronate biosynthetic process; • gastrulation with mouth forming second; • metabolaeth; • UDP-glucose metabolic process; • glycosaminoglycan biosynthetic process; • electron transport chain; • heparan sulfate proteoglycan biosynthetic process; • chondroitin sulfate biosynthetic process; • protein hexamerization; • carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologau
	7358
	n/a
	ENSG00000109814
	n/a
	O60701
	n/a
	NM_001184700; NM_001184701; NM_003359
	n/a
	NP_001171629; NP_001171630; NP_003350
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UGDH yw UGDH a elwir hefyd yn UDP-glucose 6-dehydrogenase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4p14.^[2]

Ffeithiau sydyn Strwythurau, PDB ...

Cau

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UGDH.

GDH
UGD
UDPGDH
UDP-GlcDH

Llyfryddiaeth

"UDP-glucose dehydrogenase activity and optimal downstream cellular function require dynamic reorganization at the dimer-dimer subunit interfaces. ". J Biol Chem. 2013. PMID 24145036.
"Hysteresis and negative cooperativity in human UDP-glucose dehydrogenase. ". Biochemistry. 2013. PMID 23363239.
"Allostery and Hysteresis Are Coupled in Human UDP-Glucose Dehydrogenase. ". Biochemistry. 2017. PMID 27966912.
"Hysteresis in human UDP-glucose dehydrogenase is due to a restrained hexameric structure that favors feedback inhibition. ". Biochemistry. 2014. PMID 25478983.
"UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis.". Arthritis Res Ther. 2014. PMID 25465897.

Cyfeiriadau

[1] [1]
"Human PubMed Reference:".

[2] [2]
UGDH - Cronfa NCBI

[2]

[1]