Subfamily Taxidiinae
- Genus Taxidea
- American badger, T. taxus
Subfamily Mellivorinae
- Genus Mellivora
- Honey badger, M. capensis
Subfamily Melinae
- Genus Arctonyx
- Genus Meles
- Japanese badger, M. anakuma
- Asian badger, M. leucurus
- European badger, M. meles
Subfamily Helictidinae
- Genus Melogale
- Bornean ferret-badger, M. everetti
- Chinese ferret-badger, M. moschata
- Javan ferret-badger, M. orientalis
- Burmese ferret-badger, M. personata
- Vietnam ferret-badger, M. cucphuongensis
Subfamily Guloninae[1]
- Genus Eira
- Genus Gulo
- Genus Martes
- American marten, M. americana
- Yellow-throated marten, M. flavigula
- Beech marten, M. foina
- Nilgiri marten, M. gwatkinsii
- Pine marten, M. martes
- Japanese marten, M. melampus
- Sable, M. zibellina
- Genus Pekania
Subfamily Ictonychinae[1]
- Genus Galictis
- Greater grison, G. vittata
- Lesser grison, G. cuja
- Genus Ictonyx
- Striped polecat, I. striatus
- Saharan striped polecat, I. libycus
- Genus Lyncodon
- Patagonian weasel, L. patagonicus
- Genus Poecilogale
- African striped weasel, P. albinucha
- Genus Vormela
- Marbled polecat, V. peregusna
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Subfamily Lutrinae (otters)
- Genus Aonyx
- African clawless otter, A. capensis
- Oriental small-clawed otter, A. cinerea
- Genus Enhydra
- Genus Lontra
- North American river otter, L. canadensis
- Southern river otter, L. provocax
- Neotropical otter, L. longicaudis
- Marine otter, L. felina
- Genus Lutra
- Eurasian otter, L. lutra
- Hairy-nosed otter, L. sumatrana
- Genus Hydrictis
- Spotted-necked otter, H. maculicollis
- Genus Lutrogale
- Smooth-coated otter, L. perspicillata
- Genus Pteronura
- Giant otter, P. brasiliensis
Subfamily Mustelinae
- Genus Mustela
- Amazon weasel, M. africana
- Mountain weasel, M. altaica
- Stoat (ermine), M. erminea
- Steppe polecat, M. eversmannii
- Colombian weasel, M. felipei
- Long-tailed weasel, M. frenata
- Japanese weasel, M. itatsi
- Yellow-bellied weasel, M. kathiah
- European mink, M. lutreola
- Indonesian mountain weasel, M. lutreolina
- Black-footed ferret, M. nigripes
- Least weasel, M. nivalis
- Malayan weasel, M. nudipes
- European polecat, M. putorius
- Domesticated ferret, M. p. furo
- Siberian weasel, M. sibirica
- Back-striped weasel, M. strigidorsa
- Egyptian weasel, M. subpalmata
- Genus Neovison
- American mink, N. vison
- Sea mink, N. macrodon (19th-century †)
Fossil mustelids
Extinct genera of the family Mustelidae include:
- Brachypsalis
- Chamitataxus
- Cyrnaonyx
- Ekorus
- Megalictis
- Oligobunis
- Potamotherium
- Sthenictis
- Teruelictis
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