(R,R)-butanediol dehydrogenase

In enzymology, a (R,R)-butanediol dehydrogenase (EC 1.1.1.4) is an enzyme that catalyzes the chemical reaction

(R,R)-butane-2,3-diol + NAD⁺ ${\displaystyle \rightleftharpoons }$ (R)-acetoin + NADH + H⁺

(R,R)-butanediol dehydrogenase
Meso-2,3-butanediol dehydrogenase from Klebsiella pneumoniae. PDB 1geg
Identifiers
EC no.	1.1.1.4
CAS no.	37250-09-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are (R,R)-butane-2,3-diol and NAD⁺, whereas its 3 products are (R)-acetoin, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R,R)-butane-2,3-diol:NAD⁺ oxidoreductase. Other names in common use include butyleneglycol dehydrogenase, D-butanediol dehydrogenase, D-(−)-butanediol dehydrogenase, butylene glycol dehydrogenase, diacetyl (acetoin) reductase, D-aminopropanol dehydrogenase, D-aminopropanol dehydrogenase, 1-amino-2-propanol dehydrogenase, 2,3-butanediol dehydrogenase, D-1-amino-2-propanol dehydrogenase, (R)-diacetyl reductase, (R)-2,3-butanediol dehydrogenase, D-1-amino-2-propanol:NAD⁺ oxidoreductase, 1-amino-2-propanol oxidoreductase, and aminopropanol oxidoreductase. This enzyme participates in butanoic acid metabolism.

References

• Strecker HJ, Harary I (November 1954). "Bacterial butylene glycol dehydrogenase and diacetyl reductase". The Journal of Biological Chemistry. 211 (1): 263–70. doi:10.1016/S0021-9258(18)71216-7. PMID 13211662.
• Taylor MB, Juni E (April 1960). "Stereoisomeric specificities of 2,3-butanediol dehydrogenases". Biochimica et Biophysica Acta. 39 (3): 448–57. doi:10.1016/0006-3002(60)90197-9. PMID 13837186.