3-oxo-5beta-steroid 4-dehydrogenase - Wikiwand
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3-oxo-5beta-steroid 4-dehydrogenase

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3-oxo-5-beta-steroid 4-dehydrogenase
EC number1.3.99.6
CAS number9067-97-4
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a 3-oxo-5beta-steroid 4-dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

a 3-oxo-5beta-steroid + acceptor a 3-oxo-Delta4-steroid + reduced acceptor

Thus, the two substrates of this enzyme are 3-oxo-5beta-steroid and acceptor, whereas its two products are 3-oxo-Delta4-steroid and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is 3-oxo-5beta-steroid:acceptor Delta4-oxidoreductase. This enzyme is also called 3-oxo-5beta-steroid:(acceptor) Delta4-oxidoreductase. This enzyme participates in 3 metabolic pathways: bile acid biosynthesis, c21-steroid hormone metabolism, and androgen and estrogen metabolism.


  • Davidson SJ, Talalay P (1966). "Purification and mechanism of action of a steroid delta-4-5-beta-dehydrogenase". J. Biol. Chem. 241 (4): 906–15. PMID 5907467.

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3-oxo-5beta-steroid 4-dehydrogenase
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