Alpha blocker
Class of pharmacological agents / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Alpha blocker?
Summarize this article for a 10 year old
Alpha-blockers, also known as α-blockers or α-adrenoreceptor antagonists, are a class of pharmacological agents that act as antagonists on α-adrenergic receptors (α-adrenoceptors).[2]
Alpha blockers α-blockers | |
---|---|
Drug class | |
Class identifiers | |
Use | • Hypertension • Vasoconstriction • BPH • Raynaud's Disease • Pheochromocytoma • CHF • Erectile Dysfunction |
Mechanism of action | • Receptor antagonist • Inverse agonist • Neutral antagonist |
Biological target | α-adrenoceptors |
Legal status | |
In Wikidata |
Historically, alpha-blockers were used as a tool for pharmacologic research to develop a greater understanding of the autonomic nervous system. Using alpha blockers, scientists began characterizing arterial blood pressure and central vasomotor control in the autonomic nervous system.[3] Today, they can be used as clinical treatments for a limited number of diseases.[2]
Alpha blockers can treat a small range of diseases such as hypertension, Raynaud's disease, benign prostatic hyperplasia (BPH) and erectile dysfunction.[2] Generally speaking, these treatments function by binding an α-blocker to α receptors in the arteries and smooth muscle. Ultimately, depending on the type of alpha receptor, this relaxes the smooth muscle or blood vessels, which increases fluid flow in these entities.[2]