Amidophosphoribosyltransferase
Mammalian protein found in Homo sapiens / From Wikipedia, the free encyclopedia
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Amidophosphoribosyltransferase (ATase), also known as glutamine phosphoribosylpyrophosphate amidotransferase (GPAT), is an enzyme responsible for catalyzing the conversion of 5-phosphoribosyl-1-pyrophosphate (PRPP) into 5-phosphoribosyl-1-amine (PRA), using the amine group from a glutamine side-chain. This is the committing step in de novo purine synthesis. In humans it is encoded by the PPAT (phosphoribosyl pyrophosphate amidotransferase) gene.[5][6] ATase is a member of the purine/pyrimidine phosphoribosyltransferase family.
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