Argininosuccinate synthase
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Argininosuccinate synthase or synthetase (ASS; EC 6.3.4.5) is an enzyme that catalyzes the synthesis of argininosuccinate from citrulline and aspartate. In humans, argininosuccinate synthase is encoded by the ASS gene located on chromosome 9.
Quick Facts Identifiers, EC no. ...
Argininosuccinate synthetase | |||||||||
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Identifiers | |||||||||
EC no. | 6.3.4.5 | ||||||||
CAS no. | 9023-58-9 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Quick Facts Identifiers, Symbol ...
Argininosuccinate synthetase 1 | |||||||
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Identifiers | |||||||
Symbol | ASS1 | ||||||
NCBI gene | 445 | ||||||
HGNC | 758 | ||||||
OMIM | 603470 | ||||||
RefSeq | NM_000050 | ||||||
UniProt | P00966 | ||||||
Other data | |||||||
EC number | 6.3.4.5 | ||||||
Locus | Chr. 9 q34.1 | ||||||
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Quick Facts Identifiers, Symbol ...
Argininosuccinate synthetase | |||||||||
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Identifiers | |||||||||
Symbol | Arginosuc_synth | ||||||||
Pfam | PF00764 | ||||||||
Pfam clan | CL0039 | ||||||||
InterPro | IPR001518 | ||||||||
PROSITE | PDOC00488 | ||||||||
SCOP2 | 1kp2 / SCOPe / SUPFAM | ||||||||
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ASS is responsible for the third step of the urea cycle and one of the reactions of the citrulline-NO cycle.