Azelastine
Chemical compound / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Azelastine?
Summarize this article for a 10 year old
Azelastine, sold under the brand name Optivar among others, is a H1 receptor-blocking medication primarily used as a nasal spray to treat allergic rhinitis (hay fever) and as eye drops for allergic conjunctivitis.[4][5] Other uses may include asthma and skin rashes for which it is taken by mouth.[6] Onset of effects is within minutes when used in the eyes and within an hour when used in the nose.[7] Effects last for up to 12 hours.[7]
Clinical data | |
---|---|
Trade names | Astelin, Optivar, Allergodil, others.[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a603009 |
License data |
|
Pregnancy category |
|
Routes of administration | Eye drops, nasal spray, by mouth |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 40% (intranasal) [3] |
Metabolites | desmethylazelastine (active) [3] |
Onset of action | Within 1 hour [3] |
Elimination half-life | 22 hours [3] |
Duration of action | 12 hours [3] |
Identifiers | |
| |
CAS Number |
|
PubChem CID | |
IUPHAR/BPS | |
DrugBank |
|
ChemSpider | |
UNII |
|
KEGG | |
ChEBI |
|
ChEMBL |
|
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.133.278 |
Chemical and physical data | |
Formula | C22H24ClN3O |
Molar mass | 381.90 g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
Common side effects include headache, sleepiness, change in taste, and sore throat.[7] It is unclear if use is safe during pregnancy or breastfeeding.[8] It is a second-generation antihistamine and works by blocking the release of a number of inflammatory mediators including histamine.[6][7]
Azelastine was patented in 1971 and came into medical use in 1986.[9] It is available as a generic medication[2] in the United States. In 2021, it was the 145th most commonly prescribed medication in the United States, with more than 4 million prescriptions.[10][11]