Barton decarboxylation
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The Barton decarboxylation is a radical reaction in which a carboxylic acid is converted to a thiohydroxamate ester (commonly referred to as a Barton ester). The product is then heated in the presence of a radical initiator and a suitable hydrogen donor to afford the decarboxylated product.[1][2] This is an example of a reductive decarboxylation. Using this reaction it is possible to remove carboxylic acid moieties from alkyl groups and replace them with other functional groups.[3][4] (See Scheme 1) This reaction is named after its developer, the British chemist and Nobel laureate Sir Derek Barton (1918–1998).
Quick Facts Identifiers ...
Barton decarboxylation | |
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Named after | Derek Barton |
Reaction type | Substitution reaction |
Identifiers | |
Organic Chemistry Portal | barton-decarboxylation |
RSC ontology ID | RXNO:0000135 |
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