Brefeldin A
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Brefeldin A is a lactone antiviral produced by the fungus Penicillium brefeldianum.[1] Brefeldin A inhibits protein transport from the endoplasmic reticulum to the golgi complex indirectly by preventing association of COP-I coat [2] to the Golgi membrane. Brefeldin A was initially isolated with hopes to become an antiviral drug[3] but is now primarily used in research to study protein transport.
Quick Facts Names, Identifiers ...
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Preferred IUPAC name
(1R,2E,6S,10E,11aS,13S,14aR)-1,13-Dihydroxy-6-methyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f][1]oxacyclotridecin-4-one | |
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ECHA InfoCard | 100.127.053 |
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Properties | |
C16H24O4 | |
Molar mass | 280.36 g/mol |
Appearance | White to off-white crystalline powder |
Melting point | 204 to 205 °C (399 to 401 °F; 477 to 478 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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