CBS domain
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In molecular biology, the CBS domain is a protein domain found in a range of proteins in all species from bacteria to humans. It was first identified as a conserved sequence region in 1997 and named after cystathionine beta synthase, one of the proteins it is found in.[2] CBS domains are also found in a wide variety of other proteins such as inosine monophosphate dehydrogenase,[3] voltage gated chloride channels[4][5][6][7][8] and AMP-activated protein kinase (AMPK).[9][10] CBS domains regulate the activity of associated enzymatic and transporter domains in response to binding molecules with adenosyl groups such as AMP and ATP, or s-adenosylmethionine.[11]
Quick Facts Identifiers, Symbol ...
CBS domain | |||||||||||
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Identifiers | |||||||||||
Symbol | CBS | ||||||||||
Pfam | PF00571 | ||||||||||
InterPro | IPR000644 | ||||||||||
SMART | CBS | ||||||||||
PROSITE | PS51371 | ||||||||||
SCOP2 | 1zfj / SCOPe / SUPFAM | ||||||||||
CDD | cd02205 | ||||||||||
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