CXCL11
Mammalian protein found in Homo sapiens / From Wikipedia, the free encyclopedia
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C-X-C motif chemokine 11 (CXCL11) is a protein that in humans is encoded by the CXCL11 gene.[3]
C-X-C motif chemokine 11 is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T-cell alpha chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9). It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate.[4]
Gene expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α.[5] This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10.[4][6] CXCL11 is chemotactic for activated T cells. Its gene is located on human chromosome 4 along with many other members of the CXC chemokine family.[7][8]