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Chemical compound From Wikipedia, the free encyclopedia
Cannabidiphorol, the heptyl-homologue of cannabidiol was identified as a natural phytocannabinoid and named cannabidiphorol (CBDP) in 2019.[1] It had previously been reported as a synthetic compound,[2] but was not identified as a natural product prior to 2019. Recently, CBDP has been gained popularity due to it being synthesized and available on a commercial level.[3]
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Formula | C23H34O2 |
Molar mass | 342.523 g·mol−1 |
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CBDP shows weak antagonism at both cannabinoid receptors (CB1 and CB2), similar to cannabidiol (CBD). CBD, however, exhibits stronger antagonism at CB2, reaching a 33% maximum response of SR144528 versus CBDP's 23%.[4]
Both cannabinoids act as weak agonists at the serotonin 5-HT1A receptor, contributing to potential anxiolytic effects.[4]
CBDP also shows weak agonism at the dopamine D2S receptor, with potential implications for mood regulation and addiction treatments.[4]
Unexpectedly, CBDP acts as a positive allosteric modulator (PAM) at the MOR, enhancing met-enkephalin signaling by 37%, potentially affecting pain perception.[4]
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