Cdc14
From Wikipedia, the free encyclopedia
Cdc14 and Cdc14 are a gene and its protein product respectively.[1] Cdc14 is found in most of the eukaryotes. Cdc14 was defined by Hartwell in his famous screen for loci that control the cell cycle of Saccharomyces cerevisiae.[1] Cdc14 was later shown to encode a protein phosphatase. Cdc14 is dual-specificity, which means it has serine/threonine and tyrosine-directed activity. A preference for serines next to proline is reported.[2] Many early studies, especially in the budding yeast Saccharomyces cerevisiae, demonstrated that the protein plays a key role in regulating late mitotic processes.[3] However, more recent work in a range of systems suggests that its cellular function is more complex.