Celecoxib
Nonsteroidal anti-inflammatory medication / From Wikipedia, the free encyclopedia
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Celecoxib, sold under the brand name Celebrex among others, is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug (NSAID).[7] It is used to treat the pain and inflammation in osteoarthritis, acute pain in adults, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, painful menstruation, and juvenile rheumatoid arthritis.[7] It may also be used to decrease the risk of colorectal adenomas in people with familial adenomatous polyposis.[7] It is taken by mouth.[7] Benefits are typically seen within an hour.[7]
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Pronunciation | /sɛlɪˈkɒksɪb/ SEL-i-KOK-sib |
Trade names | Celebrex, Onsenal, Elyxyb, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a699022 |
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Routes of administration | By mouth |
Drug class | Cyclooxygenase-2 (COX-2) inhibitor |
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Bioavailability | Unknown[6] |
Protein binding | 97% (mainly to serum albumin)[6] |
Metabolism | Liver (mainly CYP2C9)[6] |
Elimination half-life | 7.8 hours; 11 hours (mild hepatic impairment); 13 hours (moderate-severe hepatic impairment)[6] |
Excretion | Faeces (57%), urine (27%)[6] |
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ECHA InfoCard | 100.211.644 |
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Formula | C17H14F3N3O2S |
Molar mass | 381.37 g·mol−1 |
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Common side effects include abdominal pain, nausea, and diarrhea.[7] Serious side effects may include heart attacks, strokes, gastrointestinal perforation, gastrointestinal bleeding, kidney failure, and anaphylaxis.[8][7] Use is not recommended in people at high risk for heart disease.[9][10] The risks are similar to other NSAIDs, such as ibuprofen and naproxen.[11] Use in the later part of pregnancy or during breastfeeding is not recommended.[7][1]
Celecoxib was patented in 1993 and came into medical use in 1999.[12] It is available as a generic medication.[13] In 2021, it was the 98th most commonly prescribed medication in the United States, with more than 7 million prescriptions.[14][15]