Chloride potassium symporter
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The chloride potassium symporter is a membrane transport protein of the solute carrier family 12 that is present in the S3-segment of the renal proximal tubule[1] and in the neuron.[2] It functions in renal chloride reabsorption to transport chloride across the basolateral membrane.[1] Chloride potassium symporter can lower intracellular chloride concentrations below the electrochemical equilibrium potential.[2]
The concentrations of K+ and Cl− ions are high inside the cell due to the activities of Na+/K+ ATPase and NKCC cotransporter, respectively. Hence, their net driving force acting on the K/Cl cotransporter favours the exit of both K+ and Cl− from the cell.