Cholecystokinin receptor
G-protein coupled receptor / From Wikipedia, the free encyclopedia
Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin.[1] There are two different subtypes CCKA and CCKB which are ~50% homologous:[2] Various cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug proglumide.
More information Protein, Gene ...
Protein | Gene | Tissue distribution | Preferred ligand | Function | Mechanism |
---|---|---|---|---|---|
CCKA (CCK1) | CCKAR | primarily gastrointestinal tract, lesser amounts in the CNS | sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK | stimulation of bicarb secretion, gall bladder emptying and inhibiting gut motility | Gq[3][4] |
CCKB (CCK2) | CCKBR | primarily CNS, lesser amounts in the gastrointestinal tract | gastrin ≈ CCK (receptor does not discriminate between sulfated and nonsulfated peptides) | regulation of nociception, anxiety, memory and hunger | Gq/G11[4] |
Close
Quick Facts Identifiers, Symbol ...
cholecystokinin A receptor | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | CCKAR | ||||||
NCBI gene | 886 | ||||||
HGNC | 1570 | ||||||
OMIM | 118444 | ||||||
RefSeq | NM_000730 | ||||||
UniProt | P32238 | ||||||
Other data | |||||||
Locus | Chr. 4 p15.2-p15.1 | ||||||
|
Close
Quick Facts Identifiers, Symbol ...
cholecystokinin B receptor | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | CCKBR | ||||||
NCBI gene | 887 | ||||||
HGNC | 1571 | ||||||
OMIM | 118445 | ||||||
RefSeq | NM_176875 | ||||||
UniProt | P32239 | ||||||
Other data | |||||||
Locus | Chr. 11 p15.4 | ||||||
|
Close