Dipeptidase 2

Dipeptidase 2 (DPEP2) is a protein which in humans is encoded by the DPEP2 gene.^[4]

DPEP2
Identifiers
Aliases	DPEP2, MBD2, dipeptidase 2
External IDs	OMIM: 609925; MGI: 2442042; HomoloGene: 49703; GeneCards: DPEP2; OMA:DPEP2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 67,987,394 bp[1] End 68,000,586 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood spleen right lung lymph node bone marrow upper lobe of left lung testicle appendix n/a More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity metalloexopeptidase activity dipeptidyl-peptidase activity metallopeptidase activity hydrolase activity metal ion binding dipeptidase activity Cellular component anchored component of membrane membrane Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64174 319446 Ensembl ENSG00000167261 ENSMUSG00000053687 UniProt Q9H4A9 Q8C255 RefSeq (mRNA) NM_022355 NM_001324159 NM_001369657 NM_001301204 NM_001301205 NM_176913 RefSeq (protein) NP_001311088 NP_071750 NP_001356586 NP_001288133 NP_001288134 NP_795887 Location (UCSC) Chr 16: 67.99 – 68 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D₄, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation.^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000167261 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Habib GM, Shi ZZ, Cuevas AA, Lieberman MW (July 2003). "Identification of two additional members of the membrane-bound dipeptidase family". The FASEB Journal. 17 (10): 1313–5. doi:10.1096/fj.02-0899fje. PMID 12738806. S2CID 15252871.
5. "Entrez Gene: Dipeptidase 2".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.