Δ-8-Tetrahydrocannabinol
Isomer of tetrahydrocannabinol / From Wikipedia, the free encyclopedia
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Names | |
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IUPAC name
6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol | |
Other names
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Identifiers | |
3D model (JSmol) |
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ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.165.076 |
KEGG | |
PubChem CID |
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UNII | |
CompTox Dashboard (EPA) |
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Properties | |
C21H30O2 | |
Molar mass | 314.5 g/mol |
Density | 1.0±0.1 g/cm3 |
Boiling point | 383.5±42.0 °C |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Δ-8-tetrahydrocannabinol (delta-8-THC, Δ8-THC) is a psychoactive cannabinoid found in the Cannabis plant.[1][2][3] It is an isomer of delta-9-tetrahydrocannabinol (delta-9-THC, Δ9-THC), the compound commonly known as THC, with which it co-occurs in hemp; natural quantities of ∆8-THC found in hemp are low.[4]
Psychoactive effects are similar to that of Δ9-THC, with central effects occurring by binding to cannabinoid receptors found in various regions of the brain. During the production process of converting cannabidiol extracted from hemp to ∆8-THC, toxic chemical reagents are used, which can contaminate the product. In the US, ∆8-THC products are neither mandatorily tested nor FDA approved, hence concern has been raised about their safety. In addition, as of 2022, the safety profile of regular, long-term delta-8-THC consumption is unknown.
Partial synthesis of ∆8-THC was published in 1941 by Roger Adams and colleagues at the University of Illinois. After the 2018 United States farm bill was signed, ∆8-THC products partially synthesized from compliant sources (including industrial hemp and derivative cannabidiol extracts) experienced a rise in popularity; THC products have been sold in licensed, regulated recreational cannabis and medical cannabis industries within the United States only in California, Pennsylvania, and regulated in Michigan and Oregon. According to a March 2024 study, 35% of US twelfth graders have used ∆8-THC over the past 12 months.