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Chemical compound From Wikipedia, the free encyclopedia
Diiodotyrosine (DIT) is a precursor in the production of thyroid hormone, and results from iodization of monoiodotyrosine at the other meta- position on the phenol ring.
Names | |
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Preferred IUPAC name
(2S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid | |
Identifiers | |
3D model (JSmol) |
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ChemSpider | |
ECHA InfoCard | 100.005.539 |
MeSH | Diiodotyrosine |
PubChem CID |
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UNII | |
CompTox Dashboard (EPA) |
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Properties | |
C9H9I2NO3 | |
Molar mass | 432.982 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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DIT is a modulator of the enzyme thyroid peroxidase (which is involved in the production of thyroid hormones).[1]
Triiodothyronine is formed, when diiodotyrosine is combined with monoiodotyrosine (in the colloid of the thyroid follicle).
Two molecules of DIT combine to make the thyroid hormone thyroxine ('T4' and 'T3').
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