Dog appeasing pheromone
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Dog appeasing pheromone (DAP), sometimes known as apasine, is a mixture of esters of fatty acids released by the sebaceous glands in the inter-mammary sulcus of lactating female dogs. It is secreted from between three and four days after parturition and two to five days after weaning.[1] DAP is believed to be detected by the vomeronasal organ (Jacobson's organ)[1] and has an appeasing effect on both adults and pups,[1] and assists in establishing a bond with the mother.[2]
Synthetic DAP analogues have been developed which may support dogs during some, but not all, stressful situations.[3][4][5][6][7]