Cytosolic non-specific dipeptidase (EC 3.4.13.18) also known as carnosine dipeptidase 2 is an enzyme that in humans is encoded by the CNDP2 gene.[5][6][7] This enzyme catalyses the hydrolysis of dipeptides, preferentially those containing hydrophobic amino acids. The human enzyme uses manganese ions as a cofactor.[8] In addition to its function as a peptidase, the enzyme also functions to generate N-lactoyl amino acids, such as N-lactoyl-phenylalanine, via the process of "reverse proteolysis".[9]
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Bauer K (1998). "Cytosol non-specific dipeptidase". In Barrett AJ, Rawlings ND, Woessner JF (eds.). Handbook of Proteolytic Enzymes. London: Academic Press. pp. 1520–1522.