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Ebastine
Antihistamine drug / From Wikipedia, the free encyclopedia
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Ebastine is a H1 antihistamine with low potential for causing drowsiness.
"Aleva" redirects here. For the pepper called "aleva", see Cayenne pepper.
Quick Facts Clinical data, AHFS/Drugs.com ...
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Clinical data | |
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AHFS/Drugs.com | International Drug Names |
Routes of administration | Oral |
ATC code | |
Pharmacokinetic data | |
Protein binding | Greater than 95% |
Metabolism | Hepatic (CYP3A4-mediated), to carebastine |
Elimination half-life | 15 to 19 hours (carebastine) |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.106.831 ![]() |
Chemical and physical data | |
Formula | C32H39NO2 |
Molar mass | 469.669 g·mol−1 |
3D model (JSmol) | |
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It does not penetrate the blood–brain barrier to a significant amount and thus combines an effective block of the H1 receptor in peripheral tissue with a low incidence of central side effects, i.e. seldom causing sedation or drowsiness.[1][2][3]
It was patented in 1983 by Almirall S.A and came into medical use in 1990.[4] The substance is often provided in micronised form due to poor water solubility.