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Estradiol disulfate

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Estradiol disulfate
IUPAC name
[(8R,9S,13S,14S,17S)-13-methyl-3-sulfooxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] hydrogen sulfate
Other names
E2DS; Estradiol 3,17β-disulfate
3D model (JSmol)
Molar mass 432.50 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Estradiol disulfate (E2DS), or estradiol 3,17β-disulfate, is an endogenous estrogen conjugate and metabolite of estradiol.[1] It is related to estradiol 3-sulfate and estradiol 17β-sulfate.[1] Estradiol disulfate has 0.0004% of the relative binding affinity of estradiol for the ERα, one of the two estrogen receptors (ERs).[2]

See also


  1. ^ a b Herr, F.; Revesz, C.; Manson, A. J.; Jewell, J. B. (1970), Bernstein, Seymour; Solomon, Samuel (eds.), "Biological Properties of Estrogen Sulfates", Chemical and Biological Aspects of Steroid Conjugation, Berlin, Heidelberg: Springer, pp. 368–408, doi:10.1007/978-3-642-95177-0_8, ISBN 978-3-642-95177-0, retrieved 2020-06-23
  2. ^ Durmaz V, Schmidt S, Sabri P, Piechotta C, Weber M (October 2013). "Hands-off linear interaction energy approach to binding mode and affinity estimation of estrogens". J Chem Inf Model. 53 (10): 2681–8. doi:10.1021/ci400392p. PMID 24063761.

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Estradiol disulfate
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