FOXP3 (forkhead box P3), also known as scurfin, is a protein involved in immune system responses.[5] A member of the FOX protein family, FOXP3 appears to function as a master regulator of the regulatory pathway in the development and function of regulatory T cells.[6][7][8] Regulatory T cells generally turn the immune response down. In cancer, an excess of regulatory T cell activity can prevent the immune system from destroying cancer cells. In autoimmune disease, a deficiency of regulatory T cell activity can allow other autoimmune cells to attack the body's own tissues.[9][10]
Quick Facts Available structures, PDB ...
FOXP3 |
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Identifiers |
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Aliases | FOXP3, AIID, DIETER, IPEX, JM2, PIDX, XPID, forkhead box P3 |
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External IDs | OMIM: 300292 MGI: 1891436 HomoloGene: 8516 GeneCards: FOXP3 |
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Gene ontology |
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Molecular function | | Cellular component | | Biological process |
- negative regulation of cell population proliferation
- negative regulation of NF-kappaB transcription factor activity
- B cell homeostasis
- regulation of isotype switching to IgG isotypes
- myeloid cell homeostasis
- negative regulation of inflammatory response
- positive regulation of interleukin-4 production
- regulation of immunoglobulin production
- regulation of transcription by RNA polymerase II
- regulation of T cell anergy
- negative regulation of interleukin-6 production
- tolerance induction to self antigen
- regulation of transcription, DNA-templated
- negative regulation of DNA-binding transcription factor activity
- positive regulation of T cell tolerance induction
- negative regulation of immune response
- negative regulation of interferon-gamma production
- tolerance induction
- regulatory T cell differentiation
- positive regulation of transcription, DNA-templated
- negative regulation of interleukin-2 production
- positive regulation of histone acetylation
- negative regulation of interleukin-5 production
- negative regulation of chronic inflammatory response
- CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
- positive regulation of transcription by RNA polymerase II
- negative regulation of activated T cell proliferation
- positive regulation of gene expression
- negative regulation of interleukin-4 production
- negative regulation of interleukin-10 production
- negative regulation of tumor necrosis factor production
- T cell homeostasis
- negative regulation of CREB transcription factor activity
- negative regulation of T-helper 17 cell differentiation
- T cell activation
- positive regulation of immature T cell proliferation in thymus
- positive regulation of regulatory T cell differentiation
- negative regulation of transcription by RNA polymerase II
- positive regulation of peripheral T cell tolerance induction
- positive regulation of transforming growth factor beta1 production
- negative regulation of transcription, DNA-templated
- negative regulation of lymphocyte proliferation
- negative regulation of histone acetylation
- negative regulation of interleukin-17 production
- response to virus
- negative regulation of histone deacetylation
- CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
- positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
- negative regulation of T cell proliferation
- chromatin remodeling
- cytokine production
- negative regulation of T cell cytokine production
- negative regulation of isotype switching to IgE isotypes
- T cell receptor signaling pathway
- positive regulation of T cell anergy
- transcription, DNA-templated
- T cell mediated immunity
- negative regulation of gene expression
- anatomical structure morphogenesis
- regulation of Wnt signaling pathway
- regulation of regulatory T cell differentiation
| Sources:Amigo / QuickGO |
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Wikidata |
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While the precise control mechanism has not yet been established, FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription. In regulatory T cell model systems, the FOXP3 transcription factor occupies the promoters for genes involved in regulatory T-cell function, and may inhibit transcription of key genes following stimulation of T cell receptors.[11]