Follicular dendritic cell sarcoma
Dendritic cell sarcoma cancer that effects the follicular dendritic cells / From Wikipedia, the free encyclopedia
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Follicular dendritic cell sarcoma (FDCS) is an extremely rare neoplasm. While the existence of FDC tumors was predicted by Lennert in 1978, the tumor wasn't fully recognized as its own cancer until 1986 after characterization by Monda et al.[1][2] It accounts for only 0.4% of soft tissue sarcomas, but has significant recurrent and metastatic potential and is considered an intermediate grade malignancy.[3] The major hurdle in treating FDCS has been misdiagnosis. It is a newly characterized cancer, and because of its similarities in presentation and markers to lymphoma, both Hodgkin and Non-Hodgkin subtypes, diagnosis of FDCS can be difficult.[4] With recent advancements in cancer biology better diagnostic assays and chemotherapeutic agents have been made to more accurately diagnose and treat FDCS.[citation needed]
Follicular dendritic cell sarcoma | |
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Micrograph showing a follicular dendritic cell sarcoma. The cancer cells are larger and have pale staining nuclei. The smaller (benign) interspersed lymphocytes (darker blue) are common and suggest the diagnosis. H&E stain. | |
Specialty | Oncology |