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Succinate + acceptor <=> fumarate + reduced acceptor
Fumarate reductases can be divided into two classes depending on the electron acceptor:
- Fumarate reductase (quinol) (EC 220.127.116.11)
- The membrane-bound enzyme covalently linked to flavin cofactors, which is composed of 3 or 4 subunits, transfers electrons from a quinol to fumarate. This class of enzyme is thus involved in the production of ATP by oxidative phosphorylation.
- Fumarate reductase (NADH) (EC 18.104.22.168)
- Tielens, A.G.; van Hellemond, J.J. (1998). "The electron transport chain in anearobically functioning eukaryotes". Biochim. Biophys. Acta. 1365: 71–78. doi:10.1016/s0005-2728(98)00045-0.
- Camarasa; et al. (2007). "Role in anaerobiosis of the isoenzymes for Saccharomyces cerevisiae fumarate reductase encoded by OSM1 and FRDS1". Yeast. 24: 391–401. doi:10.1002/yea.1467.
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