GGDEF domain
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In molecular biology, the GGDEF domain is a protein domain which appears to be ubiquitous in bacteria and is often linked to a regulatory domain, such as a phosphorylation receiver or oxygen sensing domain. Its function is to act as a diguanylate cyclase and synthesize cyclic di-GMP, which is used as an intracellular signalling molecule in a wide variety of bacteria.[1][2] Enzymatic activity can be strongly influenced by the adjacent domains. Processes regulated by this domain include exopolysaccharide synthesis, biofilm formation, motility and cell differentiation.
GGDEF domain | |||||||||
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Identifiers | |||||||||
Symbol | GGDEF | ||||||||
Pfam | PF00990 | ||||||||
Pfam clan | CL0276 | ||||||||
InterPro | IPR000160 | ||||||||
SCOP2 | 1w25 / SCOPe / SUPFAM | ||||||||
CDD | cd01949 | ||||||||
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Structural studies of PleD from Caulobacter crescentus show that this domain forms a five-stranded beta sheet surrounded by helices, similar to the catalytic core of adenylate cyclase.[3]