GPR183
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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G-protein coupled receptor 183 also known as Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) is a protein (GPCR) expressed on the surface of some immune cells, namely B cells and T cells; in humans it is encoded by the GPR183 gene.[5] Expression of EBI2 is one critical mediator of immune cell localization within lymph nodes, responsible in part for the coordination of B cell, T cell, and dendritic cell movement and interaction following antigen exposure.[6][7][8][9] EBI2 is a receptor for oxysterols.[10][11] The most potent activator is 7α,25-dihydroxycholesterol (7α,25-OHC), with other oxysterols exhibiting varying affinities for the receptor.[8][7] Oxysterol gradients drive chemotaxis, attracting the EBI2-expressing cells to locations of high ligand concentration.[6][7][8][9] The GPR183 gene was identified due to its upregulation during Epstein-Barr virus infection of the Burkitt's lymphoma cell line BL41, hence its name: EBI2.[12]