Histidine triad nucleotide-binding protein 1 also known as adenosine 5'-monophosphoramidase is an enzyme that in humans is encoded by the HINT1 gene.[5][6]
Quick Facts Available structures, PDB ...
HINT1 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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1AV5, 1KPA, 1KPB, 1KPC, 1KPE, 1KPF, 3TW2, 4EQE, 4EQG, 4EQH, 4ZKL, 4ZKV, 5I2E, 5I2F |
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Identifiers |
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Aliases | HINT1, HINT, NMAN, PKCI-1, PRKCNH1, histidine triad nucleotide binding protein 1 |
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External IDs | OMIM: 601314; MGI: 1321133; HomoloGene: 3904; GeneCards: HINT1; OMA:HINT1 - orthologs |
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Wikidata |
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HINT1 hydrolyzes purine nucleotide phosphoramidates with a single phosphate group.[7] In addition, functions as scaffolding protein that modulates transcriptional activation.[8]
It is a haploinsufficient tumor suppressor gene that inhibits the Wnt/β-catenin pathway in colon cancer cells and microphthalmia-associated transcription factor (MITF) activity in human mast cells.[9][10] In the LysRS-Ap4A-MITF signaling pathway, HINT1 inhibits the MITF transcriptional activity by direct association. Upon pathway activation, HINT1 is released from MITF by diadenosine tetraphosphate (Ap4A), produced by LysRS.[10][11]