Inositol-polyphosphate multikinase

Inositol-polyphosphate multikinase (EC 2.7.1.151, IpK2, IP3/IP4 6-/3-kinase, IP3/IP4 dual-specificity 6-/3-kinase, IpmK, ArgRIII, AtIpk2alpha, AtIpk2beta, inositol polyphosphate 6-/3-/5-kinase) is an enzyme with systematic name ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

2 ATP + 1D-myo-inositol 1,4,5-trisphosphate ${\displaystyle \rightleftharpoons }$ 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (overall reaction)

(1a) ATP + 1D-myo-inositol 1,4,5-trisphosphate ${\displaystyle \rightleftharpoons }$ ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate

(1b) ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate ${\displaystyle \rightleftharpoons }$ ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

Inositol-polyphosphate multikinase
Identifiers
EC no.	2.7.1.151
CAS no.	9077-69-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown.

References

1. Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH (November 1999). "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases". Current Biology. 9 (22): 1323–6. doi:10.1016/S0960-9822(00)80055-X. PMID 10574768.
2. Odom AR, Stahlberg A, Wente SR, York JD (March 2000). "A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control". Science. 287 (5460): 2026–9. doi:10.1126/science.287.5460.2026. PMID 10720331.
3. Stevenson-Paulik J, Odom AR, York JD (November 2002). "Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases". The Journal of Biological Chemistry. 277 (45): 42711–8. doi:10.1074/jbc.M209112200. PMID 12226109.
4. Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW (January 2005). "The pathway for the production of inositol hexakisphosphate in human cells". The Journal of Biological Chemistry. 280 (3): 1911–20. doi:10.1074/jbc.M411528200. PMID 15531582.