Isopropylmalic acid (isopropylmalate) is an intermediate in the biosynthesis of leucine,[1] synthesized from oxoisovalerate by 2-isopropylmalate synthase and converted into isopropyl-3-oxosuccinate by 3-isopropylmalate dehydrogenase. Two isomers are important, the 2- and 3-isopropyl derivatives, and these are interconverted by isopropylmalate dehydratase.
2-Isopropylmalic acid | |
3-Isopropylmalic acid | |
Names | |
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IUPAC names
3-Isopropylmalic acid 2-Hydroxy-3-isopropylsuccinic acid | |
Other names
Isopropylmalate | |
Identifiers | |
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3D model (JSmol) |
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ChEBI |
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ChemSpider | |
DrugBank |
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ECHA InfoCard | 100.159.209 |
EC Number |
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PubChem CID |
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UNII |
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CompTox Dashboard (EPA) |
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Properties | |
C7H12O5 | |
Molar mass | 176.168 g·mol−1 |
Hazards | |
GHS labelling: | |
Warning | |
H315, H319, H335 | |
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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References
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