Latent TGF-beta binding protein

The latent TGF-beta binding proteins (LTBP) are a family of carrier proteins.^[1][2]

LTBP is a family of secreted multidomain proteins that were originally identified by their association with the latent form of transforming growth factors. They interact with a variety of extracellular matrix proteins and may play a role in the regulation of TGF beta bioavailability.

Genes

latent transforming growth factor beta binding protein 1 Identifiers Symbol LTBP1 Alt. symbols TGF-beta1-BP-1 NCBI gene 4052 HGNC 6714 OMIM 150390 RefSeq NM_206943 UniProt Q14766 Other data Locus Chr. 2 p22-p21 Search for Structures Swiss-model Domains InterPro

latent transforming growth factor beta binding protein 2 Identifiers Symbol LTBP2 Alt. symbols LTBP3, C14orf141 NCBI gene 4053 HGNC 6715 OMIM 602091 RefSeq NM_000428 UniProt Q14767 Other data Locus Chr. 14 q24.3 Search for Structures Swiss-model Domains InterPro

latent transforming growth factor beta binding protein 3 Identifiers Symbol LTBP3 Alt. symbols LTBP2 NCBI gene 4054 HGNC 6716 OMIM 602090 RefSeq NM_021070 UniProt Q9NS15 Other data Locus Chr. 11 q12 Search for Structures Swiss-model Domains InterPro

latent transforming growth factor beta binding protein 4 Identifiers Symbol LTBP4 Alt. symbols LTBP-4, LTBP-4L NCBI gene 8425 HGNC 6717 OMIM 604710 RefSeq NM_003573 UniProt Q8N2S1 Other data Locus Chr. 19 q13.1-13.2 Search for Structures Swiss-model Domains InterPro

References

1. Rifkin DB (March 2005). "Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability". J. Biol. Chem. 280 (9): 7409–12. doi:10.1074/jbc.R400029200. PMID 15611103.
2. Todorovic V, Jurukovski V, Chen Y, Fontana L, Dabovic B, Rifkin DB (January 2005). "Latent TGF-beta binding proteins". Int. J. Biochem. Cell Biol. 37 (1): 38–41. doi:10.1016/j.biocel.2004.03.011. PMID 15381147.

External links

• Latent+TGF-beta+Binding+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Latent-transforming growth factor beta-binding protein 1