Lennox–Gastaut syndrome
Rare form of childhood-onset epilepsy / From Wikipedia, the free encyclopedia
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Lennox–Gastaut syndrome (LGS) is a complex, rare, and severe childhood-onset epilepsy syndrome. It is characterized by multiple and concurrent seizure types including tonic seizure, cognitive dysfunction, and slow spike waves on electroencephalogram (EEG), which are very abnormal.[1] Typically, it presents in children aged 3–5 years and most of the time persists into adulthood with slight changes in the electroclinical phenotype.[2][3] It has been associated with perinatal injuries, congenital infections, brain malformations, brain tumors, genetic disorders such as tuberous sclerosis and numerous gene mutations. Sometimes LGS is observed after infantile epileptic spasm syndrome (formerly called west syndrome). The prognosis for LGS is marked by a 5% mortality in childhood and persistent seizures into adulthood (at least 90% of adults with LGS still have seizures).[4]
Lennox–Gastaut syndrome | |
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Generalized 2.5 Hz spike and wave discharges in a child with childhood absence epilepsy | |
Specialty | Neurology |
LGS was named for neurologists William G. Lennox (Boston, US) and Henri Gastaut (Marseille, France),[5] who independently described the condition. The international LGS Awareness Day is on November 1.[6]