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From Wikipedia, the free encyclopedia
Limulus clotting factor overbar C (EC 3.4.21.84, factor C, limulus factor C) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
Limulus clotting factor overbar C | |||||||||
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Identifiers | |||||||||
EC no. | 3.4.21.84 | ||||||||
CAS no. | 115743-27-6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Limulus clotting factor C | |||||||
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Identifiers | |||||||
Organism | |||||||
Symbol | ? | ||||||
UniProt | P28175 | ||||||
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This enzyme is isolated from the hemocyte granules of the horseshoe crabs Limulus and Tachypleus, where it serves as a LPS endotoxin-sensitive trypsin type serine protease to protect the organism from bacterial infection, initiating a cascade leading to coagulin formation.[4] From the N-terminus to the C-terminus, the domains are:
This enzyme is useful in Limulus amebocyte lysate as the endotoxin-detecting element. It can be produced recombinantly.[5]
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