Membrane-bound transcription factor site-2 protease
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Membrane-bound transcription factor site-2 protease, also known as S2P endopeptidase or site-2 protease (S2P), is an enzyme (EC 3.4.24.85) encoded by the MBTPS2 gene which liberates the N-terminal fragment of sterol regulatory element-binding protein (SREBP) transcription factors from membranes.[1][2] S2P cleaves the transmembrane domain of SREPB, making it a member of the class of intramembrane proteases.[3]
Quick Facts Identifiers, Symbol ...
membrane-bound transcription factor peptidase, site 2 | |||||||
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Identifiers | |||||||
Symbol | MBTPS2 | ||||||
Alt. symbols | S2P | ||||||
NCBI gene | 51360 | ||||||
HGNC | 15455 | ||||||
OMIM | 300294 | ||||||
RefSeq | NM_015884 | ||||||
UniProt | O43462 | ||||||
Other data | |||||||
EC number | 3.4.24.85 | ||||||
Locus | Chr. X p22.1-p22.2 | ||||||
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Quick Facts S2P endopeptidase, Identifiers ...
S2P endopeptidase | |||||||||
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Identifiers | |||||||||
EC no. | 3.4.24.85 | ||||||||
CAS no. | 752251-31-3 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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S2P catalyses the following chemical reaction
- Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP)-1, SREBP-2 and forms of the transcriptional activator ATF6.
This enzyme belongs to the peptidase family M50.