Monobactam
Monocyclic β-lactam antibiotics / From Wikipedia, the free encyclopedia
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Monobactams are bacterially-produced monocyclic β-lactam antibiotics. The β-lactam ring is not fused to another ring, in contrast to most other β-lactams.[1]
Aztreonam | |
---|---|
Drug class | |
Class identifiers | |
Use | Bacterial infection |
ATC code | J01DF |
External links | |
MeSH | D008997 |
Legal status | |
In Wikidata |
Monobactams are narrow-spectrum antibiotics[2] effective only against (strictly or facultatively[3]) aerobic Gram-negative bacilli,[4][5][3] exhibiting a high level of resistance to beta-lactamases of these organisms.[3] Due to their narrow spectrum, monobactams can be used to treat infections by susceptible bacteria without disrupting the patient's microbiota.[2] Monobactams are nevertheless seldom used.[2]
Aztreonam is the principal[4] and sole commercially available member of monobactams.[6] Other monobactams include tigemonam,[7] nocardicin A, and tabtoxin.[citation needed]