Mycophenolic acid
Immunosuppressant medication / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Mycophenolic acid?
Summarize this article for a 10 year old
Mycophenolic acid is an immunosuppressant medication used to prevent rejection following organ transplantation and to treat autoimmune conditions such as Crohn's disease and lupus.[11][12] Specifically it is used following kidney, heart, and liver transplantation.[12] It can be given by mouth or by injection into a vein.[12] It comes as mycophenolate sodium and mycophenolate mofetil.[12]
Clinical data | |
---|---|
Pronunciation | /ˌmaɪkoʊfɪˈnɒlɪk/ |
Trade names | Cellcept, Myfortic, others |
Other names | MPA, Mycophenolate sodium, Mycophenolate mofetil (AAN AU), Mycophenolate mofetil (USAN US) |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601081 |
License data |
|
Pregnancy category |
|
Routes of administration | By mouth, intravenous[2] |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 72% (sodium), 94% (mofetil)[10] |
Protein binding | 82–97%[10] |
Metabolism | Liver[10] |
Elimination half-life | 17.9±6.5 hours[10] |
Excretion | Urine (93%), faeces (6%)[10] |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank |
|
ChemSpider |
|
UNII | |
KEGG |
|
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.041.912 |
Chemical and physical data | |
Formula | C17H20O6 |
Molar mass | 320.341 g·mol−1 |
3D model (JSmol) | |
| |
| |
NY (what is this?) (verify) |
Common side effects include nausea, infections, and diarrhea.[12] Other serious side effects include an increased risk of cancer, progressive multifocal leukoencephalopathy, anemia, and gastrointestinal bleeding.[12] Use during pregnancy may harm the baby.[12] It works by blocking inosine monophosphate dehydrogenase (IMPDH), which is needed by lymphocytes to make guanosine.[12]
Mycophenolic acid was initially discovered by Italian Bartolomeo Gosio in 1893.[13][14] It was rediscovered in 1945 and 1968.[14] It was approved for medical use in the United States in 1995 following the discovery of its immunosuppressive properties in the 1990s.[12][13] It is available as a generic medication.[15] In 2020, it was the 313th most commonly prescribed medication in the United States, with more than 900 thousand prescriptions.[16]