Nalmefene
Opioid antagonist / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Nalmefene?
Summarize this article for a 10 year old
Nalmefene is a medication that is used in the treatment of opioid overdose and alcohol dependence.[2][3] Nalmefene belongs to the class of opioid antagonists and can be taken by mouth, administered by injection, or delivered through nasal administration.[7]
Clinical data | |
---|---|
Trade names | Selincro, Revex, others |
Other names | Nalmetrene; 6-Desoxy-6-methylenenaltrexone; CPH-101; JF-1; Lu AA36143; NIH-10365; ORF-11676 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a605043 |
License data | |
Routes of administration | By mouth, intranasal, intramuscular injection, intravenous injection, subcutaneous |
Drug class | Opioid antagonist |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 40–50% (orally)[6] |
Protein binding | 45% |
Metabolism | Liver |
Elimination half-life | 10.8 ± 5.2 hours |
Excretion | Kidney |
Identifiers | |
| |
CAS Number |
|
PubChem CID | |
IUPHAR/BPS | |
DrugBank |
|
ChemSpider | |
UNII |
|
KEGG | |
ChEBI | |
ChEMBL |
|
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.164.948 |
Chemical and physical data | |
Formula | C21H25NO3 |
Molar mass | 339.435 g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
In terms of its chemical structure and biological activity, nalmefene is similar to another opioid antagonist called naltrexone, as they are both derivatives of opiates. However, nalmefene offers certain advantages over naltrexone. These include a longer elimination half-life, which means it stays in the body for a longer duration, improved absorption when taken by mouth, and no observed liver toxicity that is dependent on the dosage.[8]
Nalmefene is available as a generic medication.[9]