Network controllability concerns the structural controllability of a network. Controllability describes our ability to guide a dynamical system from any initial state to any desired final state in finite time, with a suitable choice of inputs. This definition agrees well with our intuitive notion of control. The controllability of general directed and weighted complex networks has recently been the subject of intense study by a number of groups in wide variety of networks, worldwide. Recent studies by Sharma et al. on multi-type biological networks (gene–gene, miRNA–gene, and protein–protein interaction networks) identified control targets in phenotypically characterized Osteosarcoma showing important role of genes and proteins responsible for maintaining tumor microenvironment.
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