Neurokinin B
Chemical compound / From Wikipedia, the free encyclopedia
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Neurokinin B (NKB) belongs in the family of tachykinin peptides. Neurokinin B is implicated in a variety of human functions and pathways such as the secretion of gonadotropin-releasing hormone.[1] Additionally, NKB is associated with pregnancy in females and maturation in young adults. Reproductive function is highly dependent on levels of both neurokinin B and also the G-protein coupled receptor ligand kisspeptin.[2] The first NKB studies done attempted to resolve why high levels of the peptide may be implicated in pre-eclampsia during pregnancy.[3] NKB, kisspeptin, and dynorphin together are found in the arcuate nucleus (ARC) known as the KNDy subpopulation. This subpopulation is targeted by many steroid hormones and works to form a network that feeds back to GnRH pulse generator.[4]
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MeSH | Neurokinin+B |
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Properties | |
C55H79N13O14S2 | |
Molar mass | 1210.43 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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